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PMID: 6769122 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 4 ·1980-04-00 ·Pages 2178-82

Meruelo D, Flieger N, Smith D, McDevitt HO

Abstract

This paper provides evidence for the involvement of immune mechanisms in conferring resistance to a spontaneous AKR leukemia. It is shown that genes in the B, J, or E subregions of the H-2 complex confer resistance to a spontaneously arisen, tissue culture-adapted AKR thymoma, BW5147. A direct correlation is demonstrated between survival to injected BW5147 cells and humoral responsiveness in various hybrids obtained from crosses of AKR mice and C57BL/10 or C3H/DiSn derived congeneic strains differing at H-2. Cellular immunity appears to play no role in resistance to the proliferation of tumor cells. It is further established that development of effective humoral immunity depends on B cells and Ly-1+, 2-, 3- helper T-cells bearing the I-Jk phenotype. These findings seem directly applicable to the spontaneous disease, and results of studies using transformed cells from an overtly leukemic AKR mouse parallel those obtained using BW1547 cells.

MeSH Terms
Animals Antibody Formation Genes, MHC Class II H-2 Antigens/genetics Isoantibodies/administration & dosage Leukemia, Experimental/immunology,prevention & control Lymphocyte Cooperation Major Histocompatibility Complex Mice Mice, Inbred AKR/immunology T-Lymphocytes/immunology
Chemicals
H-2 Antigens Isoantibodies
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Meruelo D
Flieger N
Smith D
McDevitt H O
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23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.4.2178
Published
1980-04-00
Pages
2178-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348675
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.4.2178 PMC Full Text View journal details
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