Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A-reactive cells to the I-J subregion of the H-2 gene complex.
We have shown that the Ia determinants expressed on nylon wool-purified T lymphocytes reactive to concanavalin A (Con A) in serum-free media are coded in a single I subregion of the H-2 gene complex. This region, I-J, is defined by two pairs of intra-H-2 recombinant haplotypes: H-2t3, H-2t4 and H-2i3, H-2i5, carried by B10.HTT, B10.S(9R), B10.A(3R), AND B10.A(5R), respectively. No activity against Con A-reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I-J region. This suggests that Ia antigens expressed on Con A-reactive T cells are restricted to the I-J subregion.
14 references, click to expand
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Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells.J Exp Med. 1976 Feb 1;143(2):372-81 PMID: 1082489
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Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.J Exp Med. 1976 Jun 1;143(6):1382-90 PMID: 1083887
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Ia alloantigen(s) detected on thymocytes by use of a fluorescence-activated cell sorter.J Immunol. 1975 Aug;115(2):584-9 PMID: 1097521
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Ly antigens: markers of T cell function on mouse spleen cells.J Immunol. 1975 Dec;115(6):1555-7 PMID: 1102601
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Expression of Ia antigens on T and B cells and their relationship to immune-response functions.Transplant Rev. 1976;30:101-21 PMID: 59969
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Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.J Exp Med. 1974 Nov 1;140(5):1273-84 PMID: 4547437
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A rapid method for the isolation of functional thymus-derived murine lymphocytes.Eur J Immunol. 1973 Oct;3(10):645-9 PMID: 4587740
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Tissue distribution of I region-associated antigens in the mouse.J Immunol. 1974 Jul;113(1):181-8 PMID: 4598886
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The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.Adv Immunol. 1975;20:125-95 PMID: 47219
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Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells.J Exp Med. 1976 Jan 1;143(1):218-24 PMID: 53267
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