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PMID: 1082489 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells.

The Journal of experimental medicine ·Vol. 143 ·No. 2 ·1976-02-01 ·Pages 372-81

Niederhuber JE, Frelinger JA, Dine MS, Shoffner P, Dugan E, Shreffler DC

Abstract

Genes mapping in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti-Ia serum in the presence of rabbit complement removed the splenic T-cell subpopulation responsive to Con-A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H-2K, or H-2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con-A and PHA.

MeSH Terms

Animals Antibody Specificity Cell Membrane/immunology Chromosome Mapping Complement System Proteins Concanavalin A/pharmacology Genes HLA Antigens Histocompatibility Antigens Immune Sera/pharmacology In Vitro Techniques Lectins/pharmacology Lymphocyte Activation/drug effects Mice T-Lymphocytes/drug effects,immunology

Chemicals

HLA Antigens Histocompatibility Antigens Immune Sera Lectins Concanavalin A Complement System Proteins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Niederhuber J E

Frelinger J A

Dine M S

Shoffner P

Dugan E

Shreffler D C

References (23)

23 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.143.2.372

Published

1976-02-01

Pages

372-81

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2190114

Subset

External Links

PubMed source DOI: 10.1084/jem.143.2.372 PMC Full Text View journal details

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Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells.

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