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PMID: 1118728 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition of immune responses in vitro by specific antiserums to Ia antigens.

Science (New York, N.Y.) ·Vol. 188 ·No. 4185 ·1975-04-18 ·Pages 268-70

Frelinger JA, Niederhuber JE, Shreffler DC

Abstract

Mouse antiserums prepared against Ia antigens, which are products of I (immune response) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

MeSH Terms

Animals Antibody Formation Erythrocytes/immunology Genes Genetic Linkage Histocompatibility Antigens Immune Sera Immune Tolerance Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis In Vitro Techniques Isoantibodies Isoantigens Mice Perissodactyla/immunology Spleen/immunology

Chemicals

Histocompatibility Antigens Immune Sera Immunoglobulin G Immunoglobulin M Isoantibodies Isoantigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Frelinger J A

Niederhuber J E

Shreffler D C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1118728

Published

1975-04-18

Pages

268-70

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1118728 View journal details

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Inhibition of immune responses in vitro by specific antiserums to Ia antigens.

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