A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.

The Journal of experimental medicine ·Vol. 138 ·No. 6 ·1973-12-01 ·Pages 1289-304

Sachs DH, Cone JL

Abstract

Antibodies cytotoxic for only a subpopulation of C57Bl/10 lymph node and spleen cells were detected when rat antiserum against B10.D2 was exhaustively absorbed with B10.A lymphocytes. Antibodies of similar specificity were also detected in B10.A anti-B10.D2 and in B10.A anti-C57Bl/10 alloantisera. Reactions with recombinant strains of mice indicate that the cell-surface antigen(s) responsible for this specificity is determined by gene(s) in or to the left of the Ir-1 region of the major histocompatibility complex. A variety of criteria implicate B cells as the subpopulation of lymphocytes bearing this antigen. In view of these data and the recent report by others of a T-cell alloantigen determined by gene(s) in the major histocompatibility complex, it seems possible that there may be a variety of H-2-linked alloantigens expressed preferentially on subclasses of lymphocytes.

MeSH Terms

Animals Antibody Specificity B-Lymphocytes/immunology Bone Marrow/immunology Cell Membrane/immunology Chromium Radioisotopes Cytotoxicity Tests, Immunologic Epitopes Genes Histocompatibility Isoantigens/isolation & purification Lymph Nodes/immunology Mice Mice, Inbred Strains Skin Transplantation Species Specificity Spleen/immunology Thymus Gland/immunology Transplantation, Homologous

Chemicals

Chromium Radioisotopes Epitopes Isoantigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sachs D H

Cone J L

References (27)

27 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.138.6.1289

Published

1973-12-01

Pages

1289-304

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139464

Subset

External Links

PubMed source DOI: 10.1084/jem.138.6.1289 PMC Full Text View journal details

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A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.

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