A non-T:non-B cell bears I-A, I-E, I-J, and Tla (Qa-1?) determinants.
A non-T:non-B accessory cell in peritoneal washout or spleen-cell suspensions facilitates T-cell proliferative responses to the mitogen, concanavalin A. Utilizing monoclonal antibody, we show that this accessory cell bears the same I-A- and I-E-subregion controlled determinants as found on B cells. In addition, the same accessory cell bears a Tla(Qa-1?)-region and an I-J-subregion controlled determinant. This I-J determinant is also present on splenic accessory cells involved in in vitro antibody responses to sheep red blood cells. Data in a companion paper show that not all anti-I-J sera contain antibody reactive with the accessory cell, and suggest that T cells involved in the generation of suppressor activity and accessory cells bear different I-J-subregion controlled determinants.
22 references, click to expand
-
The expression of Ia antigenic determinants on macrophages required for the in vitro antibody response.J Immunol. 1979 Apr;122(4):1342-9 PMID: 87431
-
Requirement for an Ia-bearing accessory cell in Con A-induced T cell proliferation.J Immunol. 1978 Nov;121(5):1981-9 PMID: 81859
-
Studies of Ia antigens on murine peritoneal macrophages.Scand J Immunol. 1976;5(6-7):731-43 PMID: 62388
-
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.J Exp Med. 1976 Sep 1;144(3):713-25 PMID: 1085339
-
Macrophage Ia antigens. I. macrophage populations differ in their expression of Ia antigens.J Immunol. 1978 Feb;120(2):378-84 PMID: 621385
-
Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.Curr Top Microbiol Immunol. 1978;81:115-20 PMID: 567555
-
Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell.Immunol Rev. 1978;40:153-80 PMID: 112037
-
Accessory cell dependence of lectin-induced proliferation of mouse T lymphocytes.Eur J Immunol. 1977 Jul;7(7):451-7 PMID: 302211
-
The Qa-1 antigenic system. Relation of Qa-1 phenotypes to lymphocyte sets, mitogen responses, and immune functions.J Exp Med. 1978 Oct 1;148(4):963-73 PMID: 702065
-
Immunoregulatory circuits that modulate responsiveness to suppressor cell signal. Failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit.J Exp Med. 1981 Jun 1;153(6):1547-61 PMID: 6454752
-
The immune response genes of the major histocompatibility complex.Immunol Rev. 1978;38:70-119 PMID: 75166
-
T cells in a suppressor circuit and non-T:non-B cells bear different I-J determinants.Immunogenetics. 1981;13(3):205-13 PMID: 6168576
-
Mouse epidermal Ia molecules have a bone marrow origin.Nature. 1979 Nov 15;282(5736):321-3 PMID: 503207
-
Helper and suppressor T cell factors.Springer Semin Immunopathol. 1980 May;3(1):93-127 PMID: 6792727
-
T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.J Exp Med. 1980 Aug 1;152(2):280-95 PMID: 6156984
-
Further improvements in the plaque technique for detecting single antibody-forming cells.Immunology. 1968 Apr;14(4):599-600 PMID: 5653817
-
Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.J Exp Med. 1978 Oct 1;148(4):871-7 PMID: 308990
-
Characterization of Ia-positive peritoneal exudate cells which augment concanavalin A response of T cells.Cell Immunol. 1979 Oct;47(2):416-23 PMID: 314861
-
"Panning" for lymphocytes: a method for cell selection.Proc Natl Acad Sci U S A. 1978 Jun;75(6):2844-8 PMID: 351618
-
Serological analysis of antigen-specific helper factors specific for poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] and L Glu60-LAla30-LTyr10 (GAT).Eur J Immunol. 1979 Jul;9(7):501-6 PMID: 91520
-
Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A-reactive cells to the I-J subregion of the H-2 gene complex.J Exp Med. 1976 Oct 1;144(4):1141-6 PMID: 62014
-
A subpopulation of adherent accessory cells bearing both I-A and I-E or C subregion antigens is required for antigen-specific murine T lymphocyte proliferation.J Immunol. 1978 Nov;121(5):1680-6 PMID: 81849
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
