T cells in a suppressor circuit and non-T:non-B cells bear different I-J determinants.
T cells involved in the generation of suppressor activity bear an I-J-subregion controlled determinant (e.g., J1) which is distinct from that (e.g., J2) found on non-T:non-B accessory cells. T-cell subsets examined include Ly-1 inducer and Ly-1,2 acceptor cells which collaborate to generate suppressor activity in the in vitro sheep red blood cell antibody system. Non-T:non-B accessory cells examined include accessory cells involved in concanavalin-A induced, T-cell proliferative responses and in in vitro antibody responses to sheep red blood cells. These results provide evidence for serologic and genetic complexity of the I-J subregion of the murine H-2 gene complex.
13 references, click to expand
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Selective expression of separate I-region loci in functionally different lymphocyte subpopulations.Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:497-504 PMID: 302173
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Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.J Exp Med. 1976 Sep 1;144(3):713-25 PMID: 1085339
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I-N: a newly described H-2 I subregion between K and I-A.J Exp Med. 1980 Feb 1;151(2):481-5 PMID: 6153215
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A non-T:non-B cell bears I-A, I-E, I-J, and Tla (Qa-1?) determinants.Immunogenetics. 1981;13(3):215-25 PMID: 6168577
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Contrasuppression. A novel immunoregulatory activity.J Exp Med. 1981 Jun 1;153(6):1533-46 PMID: 6454751
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Immunoregulatory circuits that modulate responsiveness to suppressor cell signal. Failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit.J Exp Med. 1981 Jun 1;153(6):1547-61 PMID: 6454752
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Nature of the T-cell receptor. Both the T-cell receptor and antigen-specific T-cell-derived factors are coded for by V genes but express anti-self idiotypes indirectly determined by major histocompatibility complex genes.Scand J Immunol. 1979;10(5):387-93 PMID: 94692
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Helper and suppressor T cell factors.Springer Semin Immunopathol. 1980 May;3(1):93-127 PMID: 6792727
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A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.J Exp Med. 1976 Sep 1;144(3):699-712 PMID: 1085338
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Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.J Exp Med. 1978 Feb 1;147(2):446-58 PMID: 415110
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Characterization of Ia-positive peritoneal exudate cells which augment concanavalin A response of T cells.Cell Immunol. 1979 Oct;47(2):416-23 PMID: 314861
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Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.J Exp Med. 1976 Sep 1;144(3):685-98 PMID: 1085337
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Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit bear an I-J-subregion controlled determinant.Immunogenetics. 1980;11(6):549-57 PMID: 6086090
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