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PMID: 6153215 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

I-N: a newly described H-2 I subregion between K and I-A.

The Journal of experimental medicine ·Vol. 151 ·No. 2 ·1980-02-01 ·Pages 481-5

Hayes CE, Bach FH

Abstract

Strong, primary mixed leukocyte culture-proliferative responses in certain K region-incompatible strain combinations led us to consider whether an I region-like locus might exist between K and I-A. Results obtained with an (A. TL X B10.D2)F1 anti-B10.BR serum provided serological evidence for a new locus; B10.T(6R)-absorbed serum retained reactivity on AQR lymphocytes. This finding demonstrates an antigen, Ia.W41, encoded by a locus, Ia-7, within a new I subregion, I-N.

MeSH Terms
Animals Antibody Specificity Chromosome Mapping Epitopes Female Genes, MHC Class II H-2 Antigens/genetics Lymphocyte Activation Lymphocyte Culture Test, Mixed Male Mice Mice, Inbred Strains
Chemicals
Epitopes H-2 Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hayes C E
Bach F H
References (11)
11 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.151.2.481
Published
1980-02-01
Pages
481-5
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185779
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.151.2.481 PMC Full Text View journal details
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