Home LiteratureArticle Details
PMID: 6864882 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their cross-reactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens.

Journal of virology ·Vol. 47 ·No. 1 ·1983-07-00 ·Pages 15-23

Cote PJ, Gerin JL

Abstract

Five nonoverlapping antigenic sites (sites I through V) of woodchuck hepatitis virus surface antigen were identified with competitive binding assays involving monoclonal antibodies. Site I contributed to cross-reactions among surface antigens of hepatitis B-like viruses infecting woodchucks, ground squirrels, and humans. At least three distinct sites (sites I, II, and III) are responsible for cross-reactions between woodchuck and ground squirrel hepatitis virus surface antigens. Sites IV and V of woodchuck hepatitis virus surface antigen are not major cross-reactive sites, suggesting that these elicit virus-specific antibodies. There were no cross-reactions with duck hepatitis B virus surface antigen.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antigens, Surface/analysis,immunology Antigens, Viral/immunology Binding, Competitive Cross Reactions Hepatitis B Surface Antigens/immunology Hepatitis Viruses/immunology Humans Marmota/microbiology Radioimmunoassay Sciuridae/microbiology
Chemicals
Antibodies, Monoclonal Antigens, Surface Antigens, Viral Hepatitis B Surface Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cote P J
Gerin J L
References (28)
28 references, click to expand
  1. Australia antigen: large-scale purification from human serum and biochemical studies of its proteins.
    J Virol. 1971 May;7(5):569-76 PMID: 5105002
  2. The heterogeneity of Australia antigen.
    J Infect Dis. 1971 Jun;123(6):671-5 PMID: 4106744
  3. Detection of additional antigenic determinants of hepatitis B antigen.
    J Immunol. 1972 Oct;109(4):842-8 PMID: 4116360
  4. Properties of an oncornavirus glycoprotein: evidence for its presence on the surface of virions and infected cells.
    Virology. 1973 Oct;55(2):464-75 PMID: 4200514
  5. Immunochemistry of the hepatitis B virus: 125I HB Ag ligand.
    J Immunol. 1974 Aug;113(2):543-53 PMID: 4845665
  6. Biophysical characterization of the adr subtype of hepatitis B antigen and preparation of anti-r sera in rabbits.
    J Immunol. 1975 Jul;115(1):100-5 PMID: 50341
  7. Subtyping of hepatitis B surface antigen and antibody by radioimmunoassay.
    Gastroenterology. 1977 Feb;72(2):290-6 PMID: 401489
  8. The demonstration of subtype (D or Y)-specific determinants on the surface of the presumed hepatitis B virus.
    J Immunol. 1977 Oct;119(4):1542-4 PMID: 70490
  9. Antigenicity of the major polypeptides of hepatitis B surface antigen (HBsAg).
    J Immunol. 1978 Feb;120(2):520-5 PMID: 74391
  10. Hepatitis B vaccines. On the threshold.
    Am J Clin Pathol. 1978 Jul;70(1 Suppl):159-69 PMID: 99023
  11. A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.
    Proc Natl Acad Sci U S A. 1978 Sep;75(9):4533-7 PMID: 212758
  12. Serological relationship of woodchuck hepatitis virus to human hepatitis B virus.
    J Virol. 1979 Oct;32(1):314-22 PMID: 94359
  13. A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.
    Proc Natl Acad Sci U S A. 1980 May;77(5):2941-5 PMID: 6930677
  14. Antigenic variants of rabies virus.
    J Exp Med. 1980 Jul 1;152(1):99-112 PMID: 6156982
  15. Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States.
    N Engl J Med. 1980 Oct 9;303(15):833-41 PMID: 6997738
  16. Structural relationships between the surface antigens of ground squirrel hepatitis virus and human hepatitis B virus.
    J Virol. 1980 Dec;36(3):787-95 PMID: 7463556
  17. Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus.
    J Virol. 1980 Dec;36(3):829-36 PMID: 7463557
  18. Efficacy of hepatitis B vaccine in prevention of early HBsAg carrier state in children. Controlled trial in an endemic area (Senegal).
    Lancet. 1981 Feb 7;1(8215):289-92 PMID: 6109938
  19. Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies.
    Nature. 1981 Apr 23;290(5808):713-7 PMID: 6163993
  20. Genetic variation among hepatitis B and related viruses.
    Ann N Y Acad Sci. 1980;354:371-8 PMID: 7013620
  21. Antigenic and structural relationships of the surface antigens of hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis virus.
    J Virol. 1981 Aug;39(2):447-54 PMID: 6168776
  22. Three recently described animal virus models for human hepatitis B virus.
    Hepatology. 1981 Mar-Apr;1(2):179-83 PMID: 7286898
  23. Woodchuck hepatitis and hepatocellular carcinoma: correlation of histologic with virologic observations.
    Hepatology. 1981 Mar-Apr;1(2):91-8 PMID: 6269981
  24. Localization and nucleotide sequence of the gene coding for the woodchuck hepatitis virus surface antigen: comparison with the gene coding for the human hepatitis B virus surface antigen.
    Proc Natl Acad Sci U S A. 1981 Sep;78(9):5315-9 PMID: 6946471
  25. Immunological cross-reactivities of woodchuck and hepatitis B viral antigens.
    Infect Immun. 1982 Feb;35(2):752-7 PMID: 6173330
  26. Delineation of four antigenic sites on a paramyxovirus glycoprotein via which monoclonal antibodies mediate distinct antiviral activities.
    J Immunol. 1982 Jun;128(6):2670-5 PMID: 6281335
  27. Conformational changes at topologically distinct antigenic sites on the influenza A/PR/8/34 virus HA molecule are induced by the binding of monoclonal antibodies.
    Virology. 1982 Apr 15;118(1):1-7 PMID: 6177092
  28. Surface antigenic determinants of mammalian "hepadnaviruses" defined by group- and class-specific monoclonal antibodies.
    J Virol. 1982 Apr;42(1):135-42 PMID: 6177867
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.47.1.15-23.1983
Published
1983-07-00
Pages
15-23
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255190
Subset
IM
Grants
NIAID NIH HHS · N01-AI-82572 · United States
External Links
PubMed source DOI: 10.1128/JVI.47.1.15-23.1983 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2