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PMID: 6177867 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Surface antigenic determinants of mammalian "hepadnaviruses" defined by group- and class-specific monoclonal antibodies.

Journal of virology ·Vol. 42 ·No. 1 ·1982-04-00 ·Pages 135-42

Cote PJ, Dapolito GM, Shih JW, Gerin JL

Abstract

The hepatitis B-like viruses (human hepatitis B virus, woodchuck hepatitis virus, ground squirrel hepatitis virus, and duck hepatitis B virus) are hepatotropic DNA viruses which have been referred to collectively as "hepadnaviruses." Using a murine monoclonal antibody (101-2) to the surface antigen of woodchuck hepatitis virus, we have shown that the surface antigens of mammalian hepadnaviruses (HBsAg, WHsAg, and GSHsAg) are antigenically related via a common determinant (HV/101). Furthermore, analysis with other monoclonal antibodies to WHsAg revealed that WHsAg and GHsAg are antigenically distinct, although the antigens had more determinants in common with each other than with HBsAg. The hepadnavirus group-specific antibody (101-2) reacted with HBsAg subtypic variants in a group-specific rather than subtype-specific manner. In conjunction with observations with an HBsAg-specific, group-reactive monoclonal antibody (BX259), the present data suggest that there are at least two group-reactive epitopes of HBsAg: one which is virus specific (HBV/259) and one which is common to two other mammalian hepadnaviruses (HV/101).

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antigens, Surface/immunology Antigens, Viral/immunology Epitopes/immunology Hepatitis B Surface Antigens/immunology Hepatitis B virus/immunology Hepatitis Viruses/immunology Hepatitis, Viral, Animal/immunology Marmota/microbiology Sciuridae/microbiology Species Specificity
Chemicals
Antibodies, Monoclonal Antigens, Surface Antigens, Viral Epitopes Hepatitis B Surface Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cote P J
Dapolito G M
Shih J W
Gerin J L
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.42.1.135-142.1982
Published
1982-04-00
Pages
135-42
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256054
Subset
IM
Grants
NIAID NIH HHS · N01-AI-82572 · United States
External Links
PubMed source DOI: 10.1128/JVI.42.1.135-142.1982 PMC Full Text View journal details
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