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PMID: 6930677 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 5 ·1980-05-00 ·Pages 2941-5

Marion PL, Oshiro LS, Regnery DC, Scullard GH, Robinson WS

Abstract

A virus given the name ground squirrel hepatitis virus (or GSHV), with many of the unique characteristics of human hepatitis B virus (HBV), has been found in Beechey ground squirrels in northern California. Common features include virus morphology, viral DNA size and structure, a virion DNA polymerase that repairs a single-stranded region in the viral DNA, crossreacting viral antigens, and persistent infection with viral antigen continuously in the blood. Although similar, GSHV and HBV Are not identical. The ground squirrel virion has a slightly greater diameter, the viral surface antigens crossreact only partially and, thus, are not identical, and GSHV DNA has two restriction endonuclease EcoRI cleavage sites in contrast to the single site in HBV DNA. Thus, GSHV is a member of the virus group that includes HBV and the virus recently found in woodchucks in the eastern United States and named woodchuck hepatitis virus. It is not yet known how closely the ground squirrel and woodchuck viruses are related.

MeSH Terms
Animals California Cross Reactions DNA, Viral/metabolism DNA-Directed DNA Polymerase/analysis Hepatitis B Surface Antigens/analysis Hepatitis B virus/isolation & purification Hepatitis Viruses/enzymology,isolation & purification,ultrastructure Hepatitis, Viral, Animal/microbiology Rodentia/microbiology Sciuridae/microbiology
Chemicals
DNA, Viral Hepatitis B Surface Antigens DNA-Directed DNA Polymerase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Marion P L
Oshiro L S
Regnery D C
Scullard G H
Robinson W S
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26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.5.2941
Published
1980-05-00
Pages
2941-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349522
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.5.2941 PMC Full Text View journal details
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