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PMID: 6732752 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Messenger RNAs coding for mouse major urinary proteins are differentially induced by testosterone.

Biochemical genetics ·Vol. 22 ·No. 3-4 ·1984-04-00 ·Pages 379-87

Clissold PM, Hainey S, Bishop JO

Abstract

We have investigated the sexual dimorphism of the mouse major urinary proteins (MUPs) by isoelectric focusing (IEF). In each of two inbred strains which have different male patterns (C57BL and BALB/c), the females show a simpler pattern with fewer prominent components. The main female component is different in each strain, and these may be the products of allelic structural genes. Treatment with testosterone induces the excretion of MUPs with the male pattern. The in vitro translation of hybrid-selected MUP mRNA was studied in the same way. Again, the female patterns were simpler than the male, and the patterns obtained with female mRNA from the two inbred strains were different. When the females were treated with testosterone, a male or male-like pattern was obtained. We argue that some MUP structural genes are quite actively transcribed in females and that the transcription of others is dependent to different degrees upon induction by testosterone.

MeSH Terms
Animals Female Genes In Vitro Techniques Liver/metabolism Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Protein Biosynthesis Proteins/genetics RNA, Messenger/genetics Sex Testosterone/pharmacology Transcription, Genetic/drug effects
Chemicals
Proteins RNA, Messenger major urinary proteins Testosterone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Clissold P M
Hainey S
Bishop J O
References (17)
17 references, click to expand
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Article Info
Journal
Biochemical genetics
Abbr.
Biochem Genet
ISSN
0006-2928
DOI
10.1007/BF00484236
Published
1984-04-00
Pages
379-87
Language
English
Region
United States
NLM ID
0126611
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00484236 View journal details
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