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PMID: 6946481 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Isolation of a cDNA clone for mouse urinary proteins: age- and sex-related expression of mouse urinary protein genes is transcriptionally controlled.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 9 ·1981-09-00 ·Pages 5425-9

Derman E

Abstract

A recombinant cDNA plasmid derived from mouse urinary protein (MUP) mRNA was isolated and used to determine the level of control of the developmentally regulated and the sex-linked expression of MUP genes by monitoring the transcription of MUP mRNA sequences in isolated liver nuclei. No transcription of MUP genes could be detected in liver nuclei of prepubescent animals whose livers do not contain measurable MUP mRNA. Transcription of MUP genes in the livers of adult male mice was 6-fold higher than in the livers of adult female mice, proportional to the difference in MUP mRNA concentrations. Transcriptional control mechanisms are therefore implicated as responsible for both the developmentally and the sex-linked changes in the expression of MUP genes.

MeSH Terms
Age Factors Animals Cloning, Molecular/methods Female Gene Expression Regulation Liver/growth & development,metabolism Male Mice Plasmids Protein Biosynthesis Proteins/genetics Proteinuria RNA, Messenger/genetics Sex Factors Transcription, Genetic
Chemicals
Proteins RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Derman E
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.9.5425
Published
1981-09-00
Pages
5425-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348758
Subset
IM
Grants
NCI NIH HHS · CA 16006-07 · United States
External Links
PubMed source DOI: 10.1073/pnas.78.9.5425 PMC Full Text View journal details
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