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PMID: 6459983 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

Human genetics ·Vol. 58 ·No. 3 ·1981-00-00 ·Pages 235-54

Gebhart E

Abstract

Data from previous studies published on the induction by mutagens of sister chromatid exchanges (SCEs) and structural chromosome damage were compared qualitatively and quantitatively. Although a good correlation between the incidence of both cytogenetic phenomena has been pointed out in many previous publications, about 30% of the agents for which comparable data were available yielded non-corresponding qualitative results concerning both indicator effects. However, even in groups with good qualitative agreement distinct quantitative differences indicated different molecular mechanisms of the formation of SCEs and breaks. Additional information supporting the importance of these differences for the validity of both indicator systems has been derived from the results obtained using strong clastogens exhibiting a low or no SCE-inducing activity and vice versa, from special observations on chromosomal breakage syndromes, and from studies on the action of known co- and anti-clastogens on SCE-induction by chemical mutagens. As a result, it has been suggested that the SCE-technique should be considered as a valuable additional method for cytogenetic mutagenicity testing, which, however, is not adequate to replace the classical methods of analysis of structural chromosome damage.

MeSH Terms
Animals Bloom Syndrome/genetics Carcinogens/pharmacology Cell Line Chromosome Aberrations Crossing Over, Genetic Down Syndrome/genetics Humans Leukemia/genetics Lymphocytes/drug effects,radiation effects Mice Mutagenicity Tests Mutagens/pharmacology Radiation, Ionizing Rats Sister Chromatid Exchange
Chemicals
Carcinogens Mutagens
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gebhart E
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00294917
Published
1981-00-00
Pages
235-54
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00294917 View journal details
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