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PMID: 511130 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Sensitivity of Bloom's syndrome lymphocytes to ethyl methanesulfonate.

Human genetics ·Vol. 50 ·No. 2 ·1979-00-00 ·Pages 151-6

Krepinsky AB, Heddle JA, German J

Abstract

Ethyl methanesulfonate induced several times as many sister chromatid exchanges (SCE's) in lymphocytes from individuals affected with Bloom's syndrome as in lymphocytes from controls or heterozygotes. In cultures of cells from an individual with Bloom's syndrome who had two populations of lymphocytes circulating in his blood--'low' cells having normal spontaneous frequencies of SCE's and 'high' cells having elevated frequencies--only the high cells showed the increased sensitivity to ethyl methanesulfonate.

MeSH Terms
Cells, Cultured Chromosomes/drug effects Crossing Over, Genetic Dwarfism/blood Erythema/blood Ethyl Methanesulfonate/pharmacology Humans Lymphocytes/ultrastructure Mutagens Photosensitivity Disorders/blood Sister Chromatid Exchange Syndrome
Chemicals
Mutagens Ethyl Methanesulfonate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Krepinsky A B
Heddle J A
German J
References (12)
12 references, click to expand
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    Cytogenet Cell Genet. 1978;20(1-6):124-40 PMID: 648171
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  9. Effect of cocultivation on sister chromatid exchange frequencies in Bloom's syndrome and normal fibroblast cells.
    Nature. 1978 Jun 15;273(5663):538-40 PMID: 661962
  10. DNA damage and repair in light-sensitive human skin disease.
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    Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12 PMID: 4140506
  12. New Giemsa method for the differential staining of sister chromatids.
    Nature. 1974 Sep 13;251(5471):156-8 PMID: 4138930
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00390236
Published
1979-00-00
Pages
151-6
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00390236 View journal details
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