Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

Nature ·Vol. 258 ·No. 5531 ·1975-11-13 ·Pages 121-5

Perry P, Evans HJ

Abstract

A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens-carcinogens. The test gives a very sensitive and rapid method for detecting chromosome mutagenicity of chemical agents and provides a powerful new method for detecting environmental mutagens.

MeSH Terms

Bromodeoxyuridine/metabolism Carcinogens/analysis Cell Line Chromatids/drug effects Chromosome Aberrations Chromosomes/drug effects,radiation effects Crossing Over, Genetic/drug effects Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Humans Mutagens/analysis Radiation Genetics Staining and Labeling X-Rays

Chemicals

Carcinogens Mutagens Bromodeoxyuridine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Perry P

Evans H J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/258121a0

Published

1975-11-13

Pages

121-5

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/258121a0 View journal details

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Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

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