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PMID: 6314262 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genes for cytochrome c oxidase subunit I, URF2, and three tRNAs in Drosophila mitochondrial DNA.

Nucleic acids research ·Vol. 11 ·No. 19 ·1983-10-11 ·Pages 6859-72

Clary DO, Wolstenholme DR

Abstract

Genes for URF2, tRNAtrp, tRNAcys, tRNAtyr and cytochrome c oxidase subunit I (COI) have been identified within a sequenced segment of the Drosophila yakuba mtDNA molecule. The five genes are arranged in the order given. Transcription of the tRNAcys and tRNAtyr genes is in the same direction as replication, while transcription of the URF2, tRNAtrp and COI genes is in the opposite direction. A similar arrangement of these genes is found in mammalian mtDNA except that in the latter, the tRNAala and tRNAasn genes are located between the tRNAtrp and tRNAcys genes. Also, a sequence found between the tRNAasn and tRNAcys genes in mammalian mtDNA, which is associated with the initiation of second strand DNA synthesis, is not found in this region of the D. yakuba mtDNA molecule. As the D. yakuba COI gene lacks a standard translation initiation codon, we consider the possibility that the quadruplet ATAA may serve this function. As in other D. yakuba mitochondrial polypeptide genes, AGA codons in the URF2 and COI genes do not correspond in position to arginine-specifying codons in the equivalent genes of mouse and yeast mtDNAs, but do most frequently correspond to serine-specifying codons.

MeSH Terms
Amino Acid Sequence Animals Base Sequence DNA Restriction Enzymes DNA, Circular/genetics DNA, Mitochondrial/genetics Drosophila/enzymology,genetics Electron Transport Complex IV/genetics Genes Nucleic Acid Conformation RNA, Transfer/genetics Transcription, Genetic
Chemicals
DNA, Circular DNA, Mitochondrial RNA, Transfer Electron Transport Complex IV DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Clary D O
Wolstenholme D R
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.19.6859
Published
1983-10-11
Pages
6859-72
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326419
Subset
IM
Grants
NIGMS NIH HHS · GM 18375 · United States
NCRR NIH HHS · RR 07092 · United States
Databases
GENBANK
J01400, J01401, J01402, J01403, J01406, J01408, V01521, X00563, X03240
External Links
PubMed source DOI: 10.1093/nar/11.19.6859 PMC Full Text View journal details
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