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PMID: 6932013 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Different pattern of codon recognition by mammalian mitochondrial tRNAs.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 6 ·1980-06-00 ·Pages 3164-6

Barrell BG, Anderson S, Bankier AT, de Bruijn MH, Chen E, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG

Abstract

Analysis of an almost complete mammalian mitochondrial DNA sequence has identified 23 possible tRNA genes and we speculate here that these are sufficient to translate all the codons of the mitochondrial genetic code. This number is much smaller than the minimum of 31 required by the wobble hypothesis. For each of the eight genetic code boxes with four codons for one amino acid we find a single specific tRNA gene with T in the first (wobble) position of the anticodon. We suggest that these tRNAs with U in the wobble position can recognize all four codons in these genetic code boxes either by a "two out of three" base interaction or by U.N wobble.

MeSH Terms
Animals Anticodon/genetics Base Sequence Biological Evolution Cattle Codon/genetics Computers DNA, Mitochondrial/analysis,genetics Genetic Code Humans Mammals/genetics Mitochondria RNA, Messenger/genetics RNA, Transfer/genetics Uridine/analogs & derivatives
Chemicals
Anticodon Codon DNA, Mitochondrial RNA, Messenger RNA, Transfer Uridine
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Barrell B G
Anderson S
Bankier A T
de Bruijn M H
Chen E
Coulson A R
Drouin J
Eperon I C
Nierlich D P
Roe B A
Sanger F
Schreier P H
Smith A J
Staden R
Young I G
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18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.6.3164
Published
1980-06-00
Pages
3164-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349574
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.6.3164 PMC Full Text View journal details
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