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PMID: 6309000 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Chromosome 3q (22-ter) encodes the human transferrin receptor.

American journal of human genetics ·Vol. 35 ·No. 4 ·1983-07-00 ·Pages 573-83

Miller YE, Jones C, Scoggin C, Morse H, Seligman P

Abstract

The human transferrin receptor is an integral membrane glycoprotein of 180,000 molecular weight (mol. wt.) formed from two subunits of 90,000 mol. wt. A clone panel of Chinese hamster-human somatic cell hybrids was screened using a single cell plating cytotoxicity assay and rabbit antiserum raised to purified human transferrin receptor. Chromosome 3 displayed the highest rate of concordance with the presence of human transferrin receptor, as assayed by cytotoxicity. Antitransferrin receptor serum-resistant segregants of chromosome 3 positive, receptor-positive hybrids were selected, using antiserum and complement. The segregants consistently lost chromosome 3. 125I human transferrin binding studies confirmed synteny between the functional human transferrin receptor and chromosome 3. Examination of hybrids with either translocated or deleted chromosome 3's allows regional mapping to 3q(22-ter).

MeSH Terms
Animals Chromosome Mapping Chromosomes, Human, 1-3 Cricetinae Cricetulus Humans Hybrid Cells Immune Sera In Vitro Techniques Rabbits/immunology Receptors, Cell Surface/genetics Receptors, Transferrin Transferrin/genetics
Chemicals
Immune Sera Receptors, Cell Surface Receptors, Transferrin Transferrin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Miller Y E
Jones C
Scoggin C
Morse H
Seligman P
References (20)
20 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1983-07-00
Pages
573-83
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685748
Subset
IM
Grants
NIADDK NIH HHS · AM-27039 · United States
NCI NIH HHS · CA-18734 · United States
NHLBI NIH HHS · HL-07085 · United States
External Links
PubMed source PMC Full Text View journal details
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