Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody.

Somatic cell genetics ·Vol. 8 ·No. 2 ·1982-03-00 ·Pages 197-206

Goodfellow PN, Banting G, Sutherland R, Greaves M, Solomon E, Povey S

Abstract

The monoclonal antibody OKT-9 has been shown to recognize the human transferrin receptor. We have exploited the species specificity of OKT-9 to map a gene controlling human transferrin receptor expression to chromosome 3, using human-mouse somatic cell hybrids. The gene for the human transferrin receptor and the gene controlling transferrin expression may be linked in humans.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Chromosome Mapping Chromosomes, Human, Pair 3 Cross Reactions Gene Expression Regulation Humans Iodine Radioisotopes Mice Precipitin Tests Radioimmunoassay Receptors, Transferrin/genetics,immunology Species Specificity

Chemicals

Antibodies, Monoclonal Iodine Radioisotopes Receptors, Transferrin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Goodfellow P N

Imperial Cancer Research Fund, London, U.K.

Banting G

Sutherland R

Greaves M

Solomon E

Povey S

Article Info

Journal

Somatic cell genetics

Abbr.

Somatic Cell Genet

ISSN

0098-0366

DOI

10.1007/BF01538677

Published

1982-03-00

Pages

197-206

Language

English

Region

United States

NLM ID

7506054

Subset

External Links

PubMed source DOI: 10.1007/BF01538677

Analysis Services

Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody.

Contact

WeChat Official Account