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PMID: 6256738 Published · ppublish English Journal Article

The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 11 ·1980-11-00 ·Pages 6468-72

Lilley DM

Abstract

The single-strand-specific endonuclease S1 from Aspergillus oryzae introduces highly selective cleavages into supercoiled covalently closed circular DNA molecules, but not into their previously linearized counterparts. The cleavage sites are inverted repeats of unit length between 9 and 13 base pairs, separated by a nonrepetitious 2-6 base pairs. Such regions may adopt hairpin or similar structures stabilized by the negative superhelix density and may constitute recognition sites for cellular proteins.

MeSH Terms
Bacteriocin Plasmids Bacteriophage phi X 174/genetics Base Sequence DNA, Single-Stranded/metabolism DNA, Superhelical DNA, Viral/genetics Endonucleases/metabolism Nucleic Acid Conformation Plasmids
Chemicals
DNA, Single-Stranded DNA, Superhelical DNA, Viral Endonucleases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lilley D M
References (37)
37 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.11.6468
Published
1980-11-00
Pages
6468-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350306
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.11.6468 PMC Full Text View journal details
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