A simple model of DNA superhelices in solution.
Closed circular DNA molecules in aqueous solution take the form of interwound superhelices over a wide range of superhelix densities. We describe a very simple model of such a superhelix in which twisting and bending forces are in balance, subject both to topological constraints and to a limitation on the distance of closet approach of the interwound duplexes of the superhelix. The model is consistent with some of the observed physical properties of closed circular DNA, and suggests that there may be severe limits to the range of allowable geometries for the superhelix structure of minimum energy.
22 references, click to expand
-
Specific folding and contraction of DNA by histones H3 and H4.Cell. 1977 Jul;11(3):609-18 PMID: 195743
-
The number of superhelical turns in native virion SV40 DNA and minicol DNA determined by the band counting method.Cell. 1976 Jun;8(2):215-26 PMID: 183892
-
Supercoiling energy and nucleosome formation: the role of the arginine-rich histone kernel.Nucleic Acids Res. 1977;4(5):1159-81 PMID: 331250
-
Elastic model of supercoiling.Proc Natl Acad Sci U S A. 1977 Jun;74(6):2397-401 PMID: 267934
-
Circular superhelical DNA.Nature. 1977 Jun 23;267(5613):727-8 PMID: 876396
-
X-ray diffraction studies of circular superhelical DNA at 300-10,000-A resolution.Nature. 1976 Nov 18;264(5583):231-4 PMID: 1004545
-
Sedimentation velocity behavior of closed circular SV40 DNA as a function of superhelix density, ionic strength, counterion and temperature.J Mol Biol. 1971 Nov 28;62(1):21-38 PMID: 4333614
-
Interaction of closed circular DNA with intercalative dyes. II. The free energy of superhelix formation in SV40 DNA.J Mol Biol. 1970 Feb 14;47(3):419-35 PMID: 4313852
-
Sedimentation coefficient of polyoma virus DNA.Biopolymers. 1967;5(10):1009-19 PMID: 4294988
-
Physical and topological properties of circular DNA.J Gen Physiol. 1966 Jul;49(6):103-25 PMID: 4290891
-
Action of nicking-closing enzyme on supercoiled and nonsupercoiled closed circular DNA: formation of a Boltzmann distribution of topological isomers.Proc Natl Acad Sci U S A. 1975 Nov;72(11):4280-4 PMID: 1060106
-
Twisted circular DNA: sedimentation coefficients and the number of twists.Proc Natl Acad Sci U S A. 1966 Apr;55(4):717-20 PMID: 4286760
-
Effects of DNA primary structure on tertiary structure.FEBS Lett. 1975 Jul 15;55(1):212-5 PMID: 166886
-
Folding of the DNA double helix in chromatin-like structures from simian virus 40.Proc Natl Acad Sci U S A. 1975 May;72(5):1843-7 PMID: 168578
-
Conformational fluctuations of DNA helix.Proc Natl Acad Sci U S A. 1975 Nov;72(11):4275-9 PMID: 172901
-
Flexibility of DNA.Biopolymers. 1974 Jan;13(1):217-26 PMID: 4818129
-
Light-scattering studies on supercoil unwinding.Biochem J. 1973 Jun;133(2):209-26 PMID: 4723772
-
Variation of the average rotation angle of the DNA helix and the superhelical turns of covalently closed cyclic lambda DNA.J Mol Biol. 1969 Jul 14;43(1):25-39 PMID: 4897794
-
The writhing number of a space curve.Proc Natl Acad Sci U S A. 1971 Apr;68(4):815-9 PMID: 5279522
-
Linking numbers and nucleosomes.Proc Natl Acad Sci U S A. 1976 Aug;73(8):2639-43 PMID: 1066673
-
Flexibility of native DNA from the sedimentation behavior as a function of molecular weight and temperature.J Mol Biol. 1968 Jul 14;35(1):111-29 PMID: 5760559
-
Effect of superhelical structure on the secondary structure of DNA rings.Biopolymers. 1967;5(8):691-6 PMID: 6063089
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
