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PMID: 6207485 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses.

Nucleic acids research ·Vol. 12 ·No. 18 ·1984-09-25 ·Pages 7269-82

Kamer G, Argos P

Abstract

Possible alignments for portions of the genomic codons in eight different plant and animal viruses are presented: tobacco mosaic, brome mosaic, alfalfa mosaic, sindbis, foot-and-mouth disease, polio, encephalomyocarditis, and cowpea mosaic viruses. Since in one of the viruses (polio) the aligned sequence has been identified as an RNA-dependent polymerase, this would imply the identification of the polymerases in the other viruses. A conserved fourteen-residue segment consisting of an Asp-Asp sequence flanked by hydrophobic residues has also been found in retroviral reverse transcriptases, a bacteriophage, influenza virus, cauliflower mosaic virus and hepatitis B virus, suggesting this span as a possible active site or nucleic acid recognition region for the polymerases. Evolutionary implications are discussed.

MeSH Terms
Animals Aphthovirus/genetics Base Sequence Encephalomyocarditis virus/genetics Genes Genes, Viral Mosaic Viruses/enzymology,genetics Poliovirus/genetics RNA-Directed DNA Polymerase/genetics Sindbis Virus/genetics Species Specificity Viruses/enzymology
Chemicals
RNA-Directed DNA Polymerase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kamer G
Argos P
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.18.7269
Published
1984-09-25
Pages
7269-82
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320156
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/12.18.7269 PMC Full Text View journal details
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