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PMID: 4447121 Published · ppublish English Journal Article

Neoplasms, differentiations and mutations.

The American journal of pathology ·Vol. 77 ·No. 1 ·1974-10-00 ·Pages 103-118

Pierce GB

Abstract

Evidence has been presented to support the concept that malignant tumors are postembryonic differentiations superimposed upon the process of tissue maintenance and renewal. Malignant stem cells are derived from normal stem cells. They have a capacity for proliferation and differentiation that operates at a different level of control than the normal. Even so, malignant stem cells are responsive to enviornmental control, suggesting that it may be possible to direct their differentiation or at least to control their ability to replicate. A tumor is a caricature of normal tissue and appears undifferentiated because of the preponderance of undifferentiated proliferating stem cells in relationship to the number of cells that have differentiated and become benign.

MeSH Terms
Animals Anura Cell Differentiation Cell Division Cell Transformation, Neoplastic DNA, Neoplasm/biosynthesis Mice Microscopy, Electron Mutation Neoplasm Transplantation Neoplasms/metabolism,pathology Oncogenic Viruses Teratoma/pathology
Chemicals
DNA, Neoplasm
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pierce G B
References (117)
117 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1974-10-00
Pages
103-118
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1910714
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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