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PMID: 5123419 Published · ppublish English Journal Article

Herpesvirus type 2 isolated from cervical tumor cells grown in tissue culture.

Science (New York, N.Y.) ·Vol. 174 ·No. 4010 ·1971-11-12 ·Pages 704-7

Aurelian L, Strandberg JD, Melendez LV, Johnson LA

Abstract

A herpesvirus has been isolated from spontaneously degenerating cultures of cervical tumor cells grown in vitro. The virus was identified as a type 2 herpesvirus on the basis of biologic properties, including plaque morphology and microtubule formation in infected HEp-2 cells, and of immunologic specificity as determined by neutralization. Herpesvirus antigens and virus particles were not seen in duplicate cultures of viable cervical tumor cells.

MeSH Terms
Antigens, Viral/analysis Carcinoma/microbiology,pathology Cells, Cultured Female Herpesviridae/immunology,isolation & purification Humans Microscopy, Electron Neutralization Tests Uterine Cervical Neoplasms/microbiology,pathology Virus Cultivation
Chemicals
Antigens, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Aurelian L
Strandberg J D
Melendez L V
Johnson L A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1971-11-12
Pages
704-7
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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