Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 1 ·1973-01-00 ·Pages 190-4

Miller G, Lipman M

Abstract

Marmoset blood leukocytes transformed in vitro by Epstein-Barr virus regularly release extracellular infectious Epstein-Barr virus with high titers of transforming activity. By comparison, human umbilical cord leukocytes and adult human leukocytes transformed by Epstein-Barr virus release either no extracellular infectious virus or small amounts, irregularly.

MeSH Terms

Animals Antigens, Viral/analysis Cell Line Cell Transformation, Neoplastic/drug effects Chloroform/pharmacology Complement Fixation Tests Ethyl Ethers/pharmacology Fluorescent Antibody Technique Haplorhini Herpesvirus 4, Human/drug effects,growth & development,immunology,isolation & purification Humans Infectious Mononucleosis/microbiology Leukocytes/microbiology Microscopy, Electron Neutralization Tests Species Specificity

Chemicals

Antigens, Viral Ethyl Ethers Chloroform

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Miller G

Lipman M

References (8)

8 references, click to expand

Immunofluorescence in cells derived from Burkitt's lymphoma.
J Bacteriol. 1966 Mar;91(3):1248-56 PMID: 4160230
Epstein-Barr viral antigen in single cell clones of two human leukocytic lines.
J Virol. 1970 Nov;6(5):699-701 PMID: 4320703
Incidence of EB virus-containing cells in primary and secondary clones of several Burkitt lymphoma cell lines.
Cancer Res. 1970 Dec;30(12):2870-5 PMID: 4321974
Occurrence of Epstein-Barr virus genomes in human lymphoblastoid cell lines.
Nat New Biol. 1972 Jun 7;237(75):189-90 PMID: 4338521
Detection of Epstein-Barr viral genome in nonproductive cells.
Nat New Biol. 1971 Sep 22;233(38):103-6 PMID: 4328798
Establishment of cell lines from normal adult human blood leukocytes by exposure to Epstein-Barr virus and neutralization by human sera with Epstein-Barr virus antibody.
Proc Soc Exp Biol Med. 1971 Sep;137(4):1459-65 PMID: 4333101
Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.
Proc Natl Acad Sci U S A. 1972 Feb;69(2):383-7 PMID: 4333982
Epstein-Barr virus antigens, marker chromosome, and interferon production in clones derived from cultured Burkitt tumor cells.
J Natl Cancer Inst. 1970 Aug;45(2):399-406 PMID: 4929380

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.70.1.190

Published

1973-01-00

Pages

190-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC433213

Subset

External Links

PubMed source DOI: 10.1073/pnas.70.1.190 PMC Full Text View journal details

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Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.

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