Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 2 ·1972-02-00 ·Pages 383-7

Miller G, Shope T, Lisco H, Stitt D, Lipman M

Abstract

Blood leukocytes of two species of new world primates, other than human, transform following exposure to Epstein-Barr virus. The transformed simian cells produce Epstein-Barr virus antigens and infectious (transforming) virus. The simian lymphoblastoid cells form multinucleate giant cells that appear to be selective sites for the production of Epstein-Barr virus. Multinucleate cells reveal intranuclear inclusions; in both species, a large proportion of giant cells contain Epstein-Barr virus antigen detectable by immunofluorescence.

MeSH Terms

Animals Antigen-Antibody Reactions Antigens, Viral/biosynthesis Cattle Cell Line Cell Transformation, Neoplastic Cells, Cultured Chromosomes/pathology Complement Fixation Tests Cytopathogenic Effect, Viral Fetus Fibroblasts/metabolism Fluorescent Antibody Technique Haplorhini/immunology Herpesviridae/pathogenicity Herpesvirus 4, Human/pathogenicity Humans Immune Sera Kidney Leukocytes/immunology,metabolism Pathology Placenta

Chemicals

Antigens, Viral Immune Sera

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Miller G

Shope T

Lisco H

Stitt D

Lipman M

References (17)

17 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.2.383

Published

1972-02-00

Pages

383-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426463

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.2.383 PMC Full Text View journal details

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Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.

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