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PMID: 4373736 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Demonstration of a genetic factor influencing spontaneous release of a xenotropic virus of mouse cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 12 ·1974-12-00 ·Pages 4925-9

Stephenson JR, Aaronson SA

Abstract

There is increasing evidence that mouse cells of different strains contain different numbers and biologic classes of naturally-integrated type-C RNA viruses. The present studies have examined the cellular regulation of one class of virus, xenotropic in host range, which is common to mice of NIH Swiss and NZB strains. This virus is spontaneously released at high level by NZB embryo cells but its production by NIH Swiss embryo cells is below detectable levels. Quantitative analysis of the chronic level of virus release by embryo cell lines established in tissue culture from genetic crosses of NIH and NZB strains has demonstrated the existence of a partially dominant gene influencing virus release. Evidence is presented indicating that this gene may act to provide a factor necessary for expression of a specific class of endogenous virus.

MeSH Terms
Animals Antibodies, Viral Antigen-Antibody Reactions Antigens, Viral/analysis Cell Line Crosses, Genetic Embryo, Mammalian Genes Genotype Humans Iodine Radioisotopes Leukemia Virus, Murine/immunology Mice/microbiology Mice, Inbred NZB Peptides/immunology Radioimmunoassay Rats Retroviridae/growth & development,immunology Species Specificity
Chemicals
Antibodies, Viral Antigens, Viral Iodine Radioisotopes Peptides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stephenson J R
Aaronson S A
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.71.12.4925
Published
1974-12-00
Pages
4925-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC434012
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.71.12.4925 PMC Full Text View journal details
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