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PMID: 4325004 Published · ppublish English Journal Article

Antibody to the RNA-dependent DNA polymerase of mammalian C-type RNA tumor viruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 5 ·1971-05-00 ·Pages 920-4

Aaronson SA, Parks WP, Scolnick EM, Todaro GJ

Abstract

Sera from rats bearing transplantable tumors induced by murine C-type tumor viruses contain an inhibitor of the activity of the viral RNA-dependent DNA polymerase. The inhibitor is shown to be an immunoglobulin (IgG) directed against the enzyme. Antiserum made in rabbits against partially purified murine leukemia virus polymerase also inhibits the polymerases of other mammalian C-type RNA-containing tumor viruses. Thus, the polymerases from different mammalian tumor viruses are antigenically related.

MeSH Terms
Animals Antibodies/analysis Chromatography, DEAE-Cellulose Complement Fixation Tests DNA Nucleotidyltransferases/antagonists & inhibitors Immunoelectrophoresis Leukemia Virus, Murine/enzymology Moloney murine leukemia virus/immunology Neoplasm Transplantation RNA, Viral Rats Rauscher Virus/immunology Sarcoma, Experimental/immunology Thymine Nucleotides/metabolism Tritium
Chemicals
Antibodies RNA, Viral Thymine Nucleotides Tritium DNA Nucleotidyltransferases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Aaronson S A
Parks W P
Scolnick E M
Todaro G J
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.68.5.920
Published
1971-05-00
Pages
920-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC389081
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.68.5.920 PMC Full Text View journal details
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