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PMID: 4113509 Published · ppublish English Journal Article

Genetic factors influencing C-type RNA virus induction.

The Journal of experimental medicine ·Vol. 136 ·No. 1 ·1972-07-01 ·Pages 175-84

Stephenson JR, Aaronson SA

Abstract

Genetic factors were studied which affect the inducibility of C-type RNA viruses from embyro cultures of mouse strains with high and low incidence of spontaneous leukemia. Virus was inducible by chemical treatment from secondary embryo cultures of several inbred strains. Both virus inducibility and the capacity of the virus to persist in cells from which it was activated were found to be inherited as dominant genetic characteristics. The results show that the factors controlling virus activation and persistence in culture also play an important role in spontaneous virus expression in the animal.

MeSH Terms
Animals Cells, Cultured Embryo, Mammalian/microbiology Genetics, Microbial Idoxuridine/pharmacology Kinetics Leukemia Virus, Murine/enzymology,growth & development Mice Mice, Inbred Strains RNA-Directed DNA Polymerase/metabolism
Chemicals
RNA-Directed DNA Polymerase Idoxuridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stephenson J R
Aaronson S A
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20 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.136.1.175
Published
1972-07-01
Pages
175-84
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139189
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.136.1.175 PMC Full Text View journal details
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