Chemical induction of focus-forming virus from nonproducer cells transformed by murine sarcoma virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 12 ·1971-12-00 ·Pages 3069-72

Aaronson SA

Abstract

Focus-forming virus can be induced by chemicals from virus-negative clonal lines of cells transformed by murine sarcoma virus. The viruses activated from such nonproducer cells have the host range and serologic properties of endogenous helper viruses of the cells rather than those of the sarcoma virus used to transform them. The evidence indicates that murine sarcoma virus-transformed nonproducer cells of two species contain the genetic information for both murine sarcoma and helper virus production in an unexpressed form.

MeSH Terms

Amines Animals Antigens, Viral/metabolism Bromodeoxyuridine Cell Line Cell Transformation, Neoplastic Clone Cells Cytosine Nucleotides Deoxyuridine Fluorouracil Gammaretrovirus/metabolism Helper Viruses/metabolism Iodine Mercaptopurine Mice Moloney murine leukemia virus/metabolism Rats Rauscher Virus/metabolism Time Factors Virus Replication

Chemicals

Amines Antigens, Viral Cytosine Nucleotides Iodine Mercaptopurine Bromodeoxyuridine Fluorouracil Deoxyuridine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Aaronson S A

References (12)

12 references, click to expand

Complement fixation and tissue culture assays for mouse leukemia viruses.
Proc Natl Acad Sci U S A. 1965 May;53(5):931-8 PMID: 4287967
Persistent infection of a rat kidney cell line with Rauscher murine leukemia virus.
J Bacteriol. 1966 Oct;92(4):1133-40 PMID: 5926742
Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses.
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1164-9 PMID: 5230142
Development of 3T3-like lines from Balb-c mouse embryo cultures: transformation susceptibility to SV40.
J Cell Physiol. 1968 Oct;72(2):141-8 PMID: 4301006
Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells.
J Virol. 1969 Nov;4(5):549-53 PMID: 4311790
Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells.
J Gen Virol. 1971 Nov;13(2):245-52 PMID: 4333712
Nonproducer clones of murine sarcoma virus transformed BALB-3T3 cells.
Virology. 1970 Sep;42(1):9-19 PMID: 4318987
Murine sarcoma virus transformation of BALB-3T3 cells: lack of dependence on murine leukemia virus.
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1236-43 PMID: 4319884
Plaque assay techniques for murine leukemia viruses.
Virology. 1970 Dec;42(4):1136-9 PMID: 4099080
Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine.
Science. 1971 Oct 8;174(4005):155-6 PMID: 4330367
Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells.
Science. 1971 Oct 8;174(4005):157-9 PMID: 5119627
Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures.
J Virol. 1970 Feb;5(2):221-5 PMID: 4317349

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.12.3069

Published

1971-12-00

Pages

3069-72

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389592

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.12.3069 PMC Full Text View journal details

Analysis Services

Chemical induction of focus-forming virus from nonproducer cells transformed by murine sarcoma virus.

Contact

WeChat Official Account