Myeloma proteins as tumor-specific transplantation antigens.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 6 ·1972-06-00 ·Pages 1540-4

Lynch RG, Graff RJ, Sirisinha S, Simms ES, Eisen HN

Abstract

BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.

MeSH Terms

Animals Antibody Specificity Antigen-Antibody Reactions Antigens Dinitrophenols Epitopes Immune Sera Immunization Immunodiffusion Immunoglobulin A Iodine Isotopes Mice Mice, Inbred Strains Multiple Myeloma/immunology Myeloma Proteins/metabolism Neoplasm Transplantation Neoplasms, Experimental/immunology Rabbits/immunology Skin Transplantation Time Factors Transplantation Immunology Transplantation, Homologous

Chemicals

Antigens Dinitrophenols Epitopes Immune Sera Immunoglobulin A Iodine Isotopes Myeloma Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Lynch R G

Graff R J

Sirisinha S

Simms E S

Eisen H N

References (15)

15 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.6.1540

Published

1972-06-00

Pages

1540-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426744

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.6.1540 PMC Full Text View journal details

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