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PMID: 5288236 Published · ppublish English Journal Article

Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 11 ·1971-11-00 ·Pages 2623-6

Schulenburg EP, Simms ES, Lynch RG, Bradshaw RA, Eisen HN

Abstract

A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The "variable" segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.

MeSH Terms
Alleles Amino Acid Sequence Amino Acids/analysis Animals Antibodies Female Haptens Immune Sera Immunoglobulins/analysis Iodine Isotopes Male Mice Mice, Inbred Strains Myeloma Proteins/analysis Neoplasms, Experimental Peptides/analysis Rabbits Species Specificity
Chemicals
Amino Acids Antibodies Haptens Immune Sera Immunoglobulins Iodine Isotopes Myeloma Proteins Peptides
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schulenburg E P
Simms E S
Lynch R G
Bradshaw R A
Eisen H N
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24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.68.11.2623
Published
1971-11-00
Pages
2623-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC389486
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.68.11.2623 PMC Full Text View journal details
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