Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.

Science (New York, N.Y.) ·Vol. 163 ·No. 3862 ·1969-01-03 ·Pages 75-8

Wikler M, Köhler H, Shinoda T, Putnam FW

Abstract

The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human gammaM-globulin is homologous to the NH(2)-terminal sequences of the gamma-chain of human and rabbit gammaG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.

MeSH Terms

Amino Acid Sequence Animals Biological Evolution Bromides Chromatography, Gel Chromatography, Ion Exchange Chymotrypsin Cyanides Humans Immunoglobulin M/analysis Macroglobulins/analysis Molecular Biology Peptides/analysis Rabbits Trypsin

Chemicals

Bromides Cyanides Immunoglobulin M Macroglobulins Peptides Chymotrypsin Trypsin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Wikler M

Köhler H

Shinoda T

Putnam F W

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.163.3862.75

Published

1969-01-03

Pages

75-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.163.3862.75 View journal details

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Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.

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