Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 12 ·1971-12-00 ·Pages 3130-5

Sirisinha S, Eisen HN

Abstract

BALB/c mice were immunized with three A-myeloma proteins of BALB/c-2 or BALB/c origin (produced by plasmacytomas MOPC-315, MOPC-460, Adj. PC-22A). Noncross reacting antibodies were formed against Proteins-315 and 460, but the response to Protein-22A was marginal. Proteins-315 and 460 have anti-dinitrophenyl activity, and their reactions with the corresponding BALB/c antibodies were inhibited by dinitrophenyl ligands. It appears that antibodies can be formed in BALB/c mice against unique "idiotypic" determinants in the ligand-binding sites of some BALB/c mycloma proteins.

MeSH Terms

Animals Antigen-Antibody Reactions Autoantibodies/metabolism Binding Sites Epitopes Goats Haptens Immune Sera Immunoglobulin G Iodine Isotopes Mice Mice, Inbred Strains Myeloma Proteins/blood,metabolism Neoplasms, Experimental/immunology Nitrophenols Plasmacytoma/immunology Protein Binding Radioimmunoassay Species Specificity

Chemicals

Autoantibodies Epitopes Haptens Immune Sera Immunoglobulin G Iodine Isotopes Myeloma Proteins Nitrophenols

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sirisinha S

Eisen H N

References (16)

16 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.12.3130

Published

1971-12-00

Pages

3130-5

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389606

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.12.3130 PMC Full Text View journal details

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