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PMID: 4029125 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Extensive DNA sequence homologies between the human Y and the long arm of the X chromosome.

The EMBO journal ·Vol. 4 ·No. 7 ·1985-07-00 ·Pages 1739-43

Geldwerth D, Bishop C, Guellaën G, Koenig M, Vergnaud G, Mandel JL, Weissenbach J

Abstract

It has been proposed that sequence homology should exist between the short arms of the human sex chromosomes, in the regions pairing at meiosis. Out of 40 clones picked at random from a collection of non-repetitive DNA sequences derived from the human Y chromosome, we have found nine sequences which show very high homology with sequences located on the X chromosome. All nine probes originate from the euchromatic part of the Y chromosome. All the homologous sequences are located within the Xq12-Xq22-24 region. None of them map to the short arm of the X chromosome. We conclude that an important part of the euchromatic region of the Y chromosome is homologous to the middle of the X chromosome long arm, possibly as a result of recent translation event(s).

MeSH Terms
Animals Base Sequence Cell Line Chromosomes, Human DNA/genetics Female Humans Hybrid Cells/cytology Male Mice Nucleic Acid Hybridization X Chromosome Y Chromosome
Chemicals
DNA
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Geldwerth D
Bishop C
Guellaën G
Koenig M
Vergnaud G
Mandel J L
Weissenbach J
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38 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1985-07-00
Pages
1739-43
Language
English
Region
England
NLM ID
8208664
PMCID
PMC554411
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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