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PMID: 3894562 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S. Review

Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.

The Journal of experimental medicine ·Vol. 162 ·No. 2 ·1985-08-01 ·Pages 528-45

Fisher DA, Hunt SW, Hood L

Abstract

We have determined the DNA sequence of a gene encoding a thymus leukemia (TL) antigen in the BALB/c mouse, and have more definitively mapped the cloned BALB/c Tla-region class I gene clusters. Analysis of the sequence shows that the Tla gene is less closely related to the H-2 genes than H-2 genes are to one another or to a Qa-2,3-region genes. The Tla gene, 17.3A, contains an apparent gene conversion. Comparison of the BALB/c Tla genes with those from C57BL shows that BALB/c has more Tla-region class I genes, and that one of the genes absent in C57BL is gene 17.3A.

MeSH Terms
Alleles Amino Acid Sequence Animals Antigens, Neoplasm/genetics Base Sequence Chromosome Deletion Chromosome Mapping Cloning, Molecular DNA/genetics Gene Conversion Genes Genetic Linkage Major Histocompatibility Complex Membrane Glycoproteins Mice Mice, Inbred BALB C/genetics Polymorphism, Genetic
Chemicals
Antigens, Neoplasm Membrane Glycoproteins thymus-leukemia antigens DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fisher D A
Hunt S W
Hood L
References (43)
43 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.2.528
Published
1985-08-01
Pages
528-45
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187753
Subset
IM
Databases
GENBANK
X02817
External Links
PubMed source DOI: 10.1084/jem.162.2.528 PMC Full Text View journal details
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