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PMID: 3468485 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells.

Nucleic acids research ·Vol. 14 ·No. 24 ·1986-12-22 ·Pages 9653-66

Mechti N, Piechaczyk M, Blanchard JM, Marty L, Bonnieu A, Jeanteur P, Lebleu B

Abstract

c-myc RNA rapidly decreases to barely detectable levels in Friend erythroleukemia cells induced to differentiate upon the addition of dimethylsulfoxide. We show here that c-myc gene is down-regulated both at the transcriptional level presumably by a block in the elongation of primary transcripts and at the post-transcriptional level by an increase in the degradation of its mRNA.

MeSH Terms
Animals Cell Differentiation Cell Division Dactinomycin/pharmacology Dimethyl Sulfoxide/pharmacology Genes, Regulator Kinetics Leukemia, Erythroblastic, Acute/genetics,pathology Leukemia, Experimental/genetics,pathology Mice Oncogenes Plasmids RNA Processing, Post-Transcriptional RNA, Messenger/genetics Transcription, Genetic/drug effects
Chemicals
RNA, Messenger Dactinomycin Dimethyl Sulfoxide
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Mechti N
Piechaczyk M
Blanchard J M
Marty L
Bonnieu A
Jeanteur P
Lebleu B
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52 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.24.9653
Published
1986-12-22
Pages
9653-66
Language
English
Region
England
NLM ID
0411011
PMCID
PMC341326
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/14.24.9653 PMC Full Text View journal details
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