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PMID: 3466178 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 23 ·1986-12-00 ·Pages 9129-33

Drebin JA, Link VC, Weinberg RA, Greene MI

Abstract

The neu oncogene encodes a 185-kDa transmembrane glycoprotein tumor antigen, termed p185. We have recently described a monoclonal antibody reactive with a cell surface domain of the p185 molecule. In vivo treatment with this anti-p185 monoclonal antibody was able to significantly inhibit the tumorigenic growth of neu-transformed NIH 3T3 cells implanted into nude mice. Such treatment had no effect on the tumorigenic growth of Ha-ras-transformed NIH 3T3 cells. Furthermore, anti-p185 antibody treatment was able to inhibit the growth of the rat neuroblastoma cells from which the neu oncogene was initially isolated. These results demonstrate that a monoclonal antibody reactive with the extracellular domain of an oncogene-encoded protein can exert a significant antitumor effect; such antibodies may prove useful in the therapy of certain malignancies.

MeSH Terms
Animals Antibodies, Monoclonal/immunology,therapeutic use Antibodies, Neoplasm/immunology Antibody Specificity Antigens, Neoplasm/immunology Antigens, Surface/immunology Mice Mice, Nude Neoplasms, Experimental/prevention & control Neuroblastoma/immunology Oncogene Proteins, Viral/immunology Rats
Chemicals
Antibodies, Monoclonal Antibodies, Neoplasm Antigens, Neoplasm Antigens, Surface Oncogene Proteins, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Drebin J A
Link V C
Weinberg R A
Greene M I
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.23.9129
Published
1986-12-00
Pages
9129-33
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC387088
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.83.23.9129 PMC Full Text View journal details
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