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PMID: 6577434 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Monoclonal antibody-directed effector cells selectively lyse human melanoma cells in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 17 ·1983-09-00 ·Pages 5407-11

Schulz G, Bumol TF, Reisfeld RA

Abstract

Monoclonal antibody 9.2.27 (mAb 9.2.27) directed to a chondroitin sulfate proteoglycan on human melanoma cells was able to suppress tumor growth in athymic (nu/nu) mice more effectively when bound with polyethylene glycol to murine effector cells than when injected alone. These "armed" effector cells also proved more effective than the monoclonal antibody in eliciting antibody-dependent cellular cytotoxicity against human melanoma target cells in vitro.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antibody-Dependent Cell Cytotoxicity Cell Line Flow Cytometry Humans Immunoglobulin G/immunology Immunotherapy Lymphocytes/immunology Melanoma/immunology,therapy Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Pancreatic Neoplasms/immunology Receptors, Fc/immunology Transplantation, Heterologous
Chemicals
Antibodies, Monoclonal Immunoglobulin G Receptors, Fc
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schulz G
Bumol T F
Reisfeld R A
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23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.17.5407
Published
1983-09-00
Pages
5407-11
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC384265
Subset
IM
Grants
NCI NIH HHS · CA28420 · United States
External Links
PubMed source DOI: 10.1073/pnas.80.17.5407 PMC Full Text View journal details
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