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PMID: 3883355 Published · ppublish English Clinical Trial Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 4 ·1985-02-00 ·Pages 1242-6

Houghton AN, Mintzer D, Cordon-Cardo C, Welt S, Fliegel B, Vadhan S, Carswell E, Melamed MR, Oettgen HF, Old LJ

Abstract

R24 is an IgG3 mouse monoclonal antibody that identifies GD3, a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin. Twelve patients with metastatic melanoma were treated with R24 at three dose levels, 8, 80, or 240 mg/m2, over a period of 2 weeks. Peak antibody levels in the serum were dose related and ranged from less than 0.1 to 62 micrograms/ml. Inflammatory reactions (urticaria, pruritus, erythema, subcutaneous ecchymoses) were observed around tumor sites in patients treated at doses greater than or equal to 80 mg/m2. Tumor biopsies during and after treatment showed lymphocyte and mast cell infiltration, mast cell degranulation, and complement deposition. Side effects were mild and were readily controlled by antihistamines. Major tumor regression has been observed in three patients.

MeSH Terms

Adult Aged Antibodies, Monoclonal/therapeutic use Antigens, Neoplasm/immunology Antigens, Surface/immunology Clinical Trials as Topic Complement Activation Female Gangliosides/immunology Humans Immunoglobulin G/administration & dosage Immunotherapy Male Melanoma/immunology,therapy Middle Aged

Chemicals

Antibodies, Monoclonal Antigens, Neoplasm Antigens, Surface Gangliosides Immunoglobulin G ganglioside, GD3

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Houghton A N

Mintzer D

Cordon-Cardo C

Welt S

Fliegel B

Vadhan S

Carswell E

Melamed M R

Oettgen H F

Old L J

References (8)

8 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.82.4.1242

Published

1985-02-00

Pages

1242-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC397231

Subset

Grants

NCI NIH HHS · CA-08748 · United States

NCI NIH HHS · CA-19267 · United States

External Links

PubMed source DOI: 10.1073/pnas.82.4.1242 PMC Full Text View journal details

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Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma.

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