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PMID: 7175440 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.

The Journal of experimental medicine ·Vol. 156 ·No. 6 ·1982-12-01 ·Pages 1755-66

Houghton AN, Eisinger M, Albino AP, Cairncross JG, Old LJ

Abstract

The surface antigens of melanocytes from newborn and adult skin have been analyzed with monoclonal antibodies detecting cell surface antigens of malignant melanoma. Antigenic markers that distinguish early, intermediate, and mature stages in melanocyte differentiation have been defined. The characteristics of the normal melanocyte precursor have been inferred from the features of melanomas that express early markers of melanocyte differentiation. A rudimentary surface antigen map of cells undergoing melanocyte differentiation and a new classification of melanomas based on the expression of melanocyte differentiation antigens are proposed.

MeSH Terms
Adult Animals Antibodies, Monoclonal/immunology Antigens, Neoplasm/analysis Antigens, Surface/analysis,classification Cell Differentiation Cell Transformation, Neoplastic/immunology Cholera Toxin/pharmacology Female Humans Infant, Newborn Melanoma/classification,immunology Mice Pregnancy Skin/cytology,immunology Tetradecanoylphorbol Acetate/pharmacology
Chemicals
Antibodies, Monoclonal Antigens, Neoplasm Antigens, Surface Cholera Toxin Tetradecanoylphorbol Acetate
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Houghton A N
Eisinger M
Albino A P
Cairncross J G
Old L J
References (17)
17 references, click to expand
  1. The tyrosine hydroxylase activity of mammalian tyrosinase.
    J Biol Chem. 1966 Jan 10;241(1):161-8 PMID: 5294951
  2. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.
    Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93 PMID: 4385242
  3. Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.
    Proc Natl Acad Sci U S A. 1976 Sep;73(9):3278-82 PMID: 1067619
  4. Study of antibodies against human melanoma produced by somatic cell hybrids.
    Proc Natl Acad Sci U S A. 1978 Jul;75(7):3405-9 PMID: 80012
  5. Serological analysis of cell surface antigens of malignant human brain tumors.
    Proc Natl Acad Sci U S A. 1978 Oct;75(10):5122-6 PMID: 283420
  6. Cell surface antigens of human melanoma identified by monoclonal antibody.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2927-31 PMID: 288077
  7. Common human melanoma-associated antigen(s) detected by monoclonal antibodies.
    Cancer Res. 1980 Jul;40(7):2523-8 PMID: 6155995
  8. Serological survey of normal humans for natural antibody to cell surface antigens of melanoma.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):4260-4 PMID: 6933476
  9. Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):6114-8 PMID: 6934537
  10. Analysis of the biosynthesis of HLA-DR glycoproteins in human malignant melanoma cell lines.
    J Immunol. 1981 Jun;126(6):2408-13 PMID: 6785352
  11. Cell surface antigens of human renal cancer defined by mouse monoclonal antibodies: identification of tissue-specific kidney glycoproteins.
    Proc Natl Acad Sci U S A. 1981 Aug;78(8):5122-6 PMID: 6946460
  12. Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens.
    J Exp Med. 1981 Dec 1;154(6):1764-78 PMID: 6976407
  13. Immunoelectron microscopic identification of Langerhans cells using a new antigenic marker.
    J Invest Dermatol. 1982 Feb;78(2):177-80 PMID: 7035574
  14. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.
    Proc Natl Acad Sci U S A. 1982 Mar;79(6):2018-22 PMID: 6952249
  15. Cell surface antigens of human astrocytoma defined by mouse monoclonal antibodies: identification of astrocytoma subsets.
    Proc Natl Acad Sci U S A. 1982 Sep;79(18):5641-5 PMID: 6182568
  16. ANTIGENIC PROPERTIES OF EXPERIMENTAL LEUKEMIAS. I. SEROLOGICAL STUDIES IN VITRO WITH SPONTANEOUS AND RADIATION-INDUCED LEUKEMIAS.
    J Natl Cancer Inst. 1963 Oct;31:977-95 PMID: 14069836
  17. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.
    J Exp Med. 1964 Sep 1;120:413-33 PMID: 14207060
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.156.6.1755
Published
1982-12-01
Pages
1755-66
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186870
Subset
IM
Grants
NCRR NIH HHS · 5S07RR05534 · United States
NCI NIH HHS · CA-08748 · United States
NCI NIH HHS · CA-19765 · United States
External Links
PubMed source DOI: 10.1084/jem.156.6.1755 PMC Full Text View journal details
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