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PMID: 3287374 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 11 ·1988-06-00 ·Pages 3738-42

Rollins BJ, Morrison ED, Stiles CD

Abstract

The platelet-derived growth factor-inducible gene JE has been widely used as a molecular marker for the cellular response to growth factors, antimitogenic agents, and other biological response modifiers; however, the structure of the JE gene and the nature of its encoded protein have not been previously described. We present here structural and regulatory features of the JE gene and its product that link it to a family of cytokines, including macrophage colony-stimulating factor, interferon alpha, interleukin 6 (also known as interferon beta 2, B-cell-stimulatory factor 2, 26-kDa protein, and hybridoma/plasmacytoma growth factor), and interleukin 2. Just as T lymphocytes secrete interleukins as a component of their response to mitogens, it appears that fibroblasts secrete cytokines as a component of their response to platelet-derived growth factor.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Products/genetics Cell Line Chemokine CCL2 Cloning, Molecular Cytokines DNA/genetics Gene Expression Regulation/drug effects Genes Glycoproteins/genetics Interleukin-1/pharmacology Mice Molecular Sequence Data Platelet-Derived Growth Factor/pharmacology RNA, Double-Stranded/pharmacology
Chemicals
Biological Products Chemokine CCL2 Cytokines Glycoproteins Interleukin-1 Platelet-Derived Growth Factor RNA, Double-Stranded DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rollins B J
Division of Medicine, Harvard Medical School, Boston, MA.
Morrison E D
Stiles C D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.11.3738
Published
1988-06-00
Pages
3738-42
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC280293
Subset
IM
Databases
GENBANK
M19681, M19682
External Links
PubMed source DOI: 10.1073/pnas.85.11.3738 PMC Full Text View journal details
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