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PMID: 3164703 Published · ppublish English Journal Article

Individual specific DNA fingerprints from a hypervariable region probe: alpha-globin 3'HVR.

Human genetics ·Vol. 79 ·No. 2 ·1988-06-00 ·Pages 142-6

Fowler SJ, Gill P, Werrett DJ, Higgs DR

Abstract

A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.

MeSH Terms
Alleles Chromosome Mapping DNA/genetics Female Genetic Linkage Genetic Markers Globins/genetics Humans Male Nucleotide Mapping
Chemicals
Genetic Markers Globins DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fowler S J
Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berks, UK.
Gill P
Werrett D J
Higgs D R
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00280553
Published
1988-06-00
Pages
142-6
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00280553 View journal details
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