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PMID: 3014536 Published · ppublish English Journal Article

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 14 ·1986-07-00 ·Pages 5165-9

Higgs DR, Wainscoat JS, Flint J, Hill AV, Thein SL, Nicholls RD, Teal H, Ayyub H, Peto TE, Falusi AG

Abstract

Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers.

MeSH Terms
Alleles DNA Restriction Enzymes Genes Genetic Linkage Genetic Markers Globins/genetics Humans Polymorphism, Genetic Recombination, Genetic
Chemicals
Genetic Markers Globins DNA Restriction Enzymes
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Higgs D R
Wainscoat J S
Flint J
Hill A V
Thein S L
Nicholls R D
Teal H
Ayyub H
Peto T E
Falusi A G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.14.5165
Published
1986-07-00
Pages
5165-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323911
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.83.14.5165 PMC Full Text View journal details
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