Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.

American journal of human genetics ·Vol. 35 ·No. 6 ·1983-11-00 ·Pages 1086-9

Wainscoat JS, Higgs DR, Kanavakis E, Cao A, Georgiou D, Clegg JB, Weatherall DJ

Abstract

A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.

MeSH Terms

Chromosome Mapping Chromosomes, Human, 16-18 Cyprus DNA/analysis,genetics DNA Restriction Enzymes Deoxyribonucleases, Type II Site-Specific Genes Globins/genetics Greece Homozygote Humans Italy Polymorphism, Genetic

Chemicals

Globins DNA DNA Restriction Enzymes Deoxyribonucleases, Type II Site-Specific GCCNNNNNGGC-specific type II deoxyribonucleases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Wainscoat J S

Higgs D R

Kanavakis E

Cao A

Georgiou D

Clegg J B

Weatherall D J

References (9)

9 references, click to expand

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Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3586-9 PMID: 6158051
Highly variable regions of DNA flank the human alpha globin genes.
Nucleic Acids Res. 1981 Sep 11;9(17):4213-24 PMID: 6272199
A common mutant EcoRI restriction endonuclease site in the 5' flanking portion of the human alpha-globin gene.
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7056-8 PMID: 6273907
Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster.
Proc Natl Acad Sci U S A. 1982 Jan;79(1):137-41 PMID: 6275383
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.
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Hum Genet. 1982;62(2):164-6 PMID: 6298095

Article Info

Journal

American journal of human genetics

Abbr.

Am J Hum Genet

ISSN

0002-9297

Published

1983-11-00

Pages

1086-9

Language

English

Region

United States

NLM ID

0370475

PMCID

PMC1685971

Subset

External Links

PubMed source PMC Full Text View journal details

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Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.

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