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PMID: 6292855 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Multiple arrangements of the human embryonic zeta globin genes.

Nucleic acids research ·Vol. 10 ·No. 19 ·1982-10-11 ·Pages 5853-68

Winichagoon P, Higgs DR, Goodbourn SE, Lamb J, Clegg JB, Weatherall DJ

Abstract

Rearrangements which are most readily explained by homologous crossover between misaligned segments of DNA in the region of the human embryonic zeta (zeta) globin genes have been identified in individuals of three different racial origins. These recombination events have resulted in a surprisingly high prevalence of chromosomes with single (0.4%) and triplicated (1.3%) zeta genes with apparently no significant effect on the phenotype.

MeSH Terms
Chromosomes, Human, 16-18 Crossing Over, Genetic DNA Restriction Enzymes Embryo, Mammalian Female Genes Humans Nucleic Acid Hybridization Pregnancy Racial Groups Thalassemia/genetics
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Winichagoon P
Higgs D R
Goodbourn S E
Lamb J
Clegg J B
Weatherall D J
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23 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.19.5853
Published
1982-10-11
Pages
5853-68
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320935
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/10.19.5853 PMC Full Text View journal details
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