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PMID: 6171809 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structure of the zeta chain of human embryonic hemoglobin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 10 ·1981-10-00 ·Pages 6076-80

Clegg JB, Gagnon J

Abstract

The complete amino acid sequence of the zeta chain of human embryonic hemoglobin has been determined. It differs from human alpha globin at 57 of the 141 residues and several of the replacements are at positions of structural or functional importance, particularly in relationship to the Bohr effect and high intrinsic oxygen affinity which are characteristic of embryonic hemoglobins. The zeta-globin sequence is more closely related to other mammalian embryonic alpha-like globins than to human alpha, suggesting that there have been strong selective pressures to maintain these embryo-specific globins since their emergence several hundred million years ago.

MeSH Terms
Amino Acid Sequence Female Fetal Hemoglobin/metabolism Genetic Variation Hemoglobins, Abnormal Humans Kinetics Macromolecular Substances Oxyhemoglobins/metabolism Peptide Fragments/analysis Pregnancy
Chemicals
Hemoglobins, Abnormal Macromolecular Substances Oxyhemoglobins Peptide Fragments Fetal Hemoglobin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Clegg J B
Gagnon J
References (32)
32 references, click to expand
  1. Complete nucleotide sequence of the human delta-globin gene.
    Cell. 1980 Oct;21(3):639-46 PMID: 7438204
  2. Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.
    Cell. 1980 Oct;21(3):627-38 PMID: 7438203
  3. The structure and evolution of the human beta-globin gene family.
    Cell. 1980 Oct;21(3):653-68 PMID: 6985477
  4. Rat brain Thy-1 glycoprotein. The amino acid sequence, disulphide bonds and an unusual hydrophobic region.
    Biochem J. 1981 Apr 1;195(1):15-30 PMID: 6118137
  5. Two new haemoglobin variants in a very young human embryo.
    Nature. 1961 Feb 11;189:496-7 PMID: 13716547
  6. Halogenation of tyrosine during acid hydrolysis.
    Biochim Biophys Acta. 1963 May 14;71:468-71 PMID: 13976292
  7. Hemoglobins of early human embryonic development.
    Science. 1966 Sep 16;153(3742):1417-8 PMID: 5917782
  8. Hemoglobin Portland 1: a new human hemoglobin unique in structure.
    Science. 1967 Jul 7;157(3784):65-6 PMID: 6026665
  9. Abnormal human haemoglobins. Separation and characterization of the alpha and beta chains by chromatography, and the determination of two new variants, hb Chesapeak and hb J (Bangkok).
    J Mol Biol. 1966 Aug;19(1):91-108 PMID: 5967288
  10. Evidence for a new haemoglobin chain (zeta-chain).
    Nature. 1970 Oct 17;228(5268):278-80 PMID: 5479523
  11. Haemoglobin F Port Royal (alpha2G gamma2 125 Glu leads to Ala).
    Br J Haematol. 1974 Jun;27(2):313-8 PMID: 4846278
  12. Evidence for a unique kind of alpha-type globin chain in early mammalian embryos.
    Nature. 1974 Aug 30;250(5469):774-6 PMID: 4413329
  13. Embryonic and fetal hemoglobin in animals.
    Ann N Y Acad Sci. 1974 Nov 29;241(0):653-71 PMID: 4139923
  14. Oxygen dissociation curve of haemoglobin Portland.
    FEBS Lett. 1975 Jan 1;49(3):390-1 PMID: 234081
  15. Oxygen dissociation properties of human embryonic red cells.
    Nature. 1975 Mar 27;254(5498):335-7 PMID: 1118015
  16. Human embryonic haemoglobins including a comparison by homology of the human beta and alpha chains.
    Nature. 1975 Aug 7;256(5517):511-3 PMID: 1160998
  17. Oxygen affinity and allosteric effects of embryonic mouse haemolglobins.
    Nature. 1975 Sep 25;257(5524):333-4 PMID: 240127
  18. Interaction of haemoglobin with protons, CO2 and 2,3-diphosphoglycerate.
    Br Med Bull. 1976 Sep;32(3):209-12 PMID: 10040
  19. Separation of human hemoglobins by DEAE-cellulose chromatography using glycine-KCN-NaC1 developers.
    Hemoglobin. 1976-1977;1(1):27-44 PMID: 1052169
  20. Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay.
    Cell. 1977 Sep;12(1):205-18 PMID: 561664
  21. The structure of horse methaemoglobin at 2-0 A resolution.
    J Mol Biol. 1977 Aug 15;114(3):385-414 PMID: 561852
  22. Further structural studies of the heavy chain of HLA antigens and its similarity to immunoglobulins.
    Proc Natl Acad Sci U S A. 1977 Sep;74(9):4002-6 PMID: 410030
  23. Automated amino acid sequence of small peptides utilizing Polybrene.
    Anal Biochem. 1978 Mar;85(1):126-31 PMID: 629377
  24. Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (polybrene), and high pressure liquid chromatography.
    Biochemistry. 1978 May 30;17(11):2124-33 PMID: 667015
  25. Embryonic hemoglobins: dependency of functional characteristics on tetramer composition.
    Pflugers Arch. 1978 Oct 18;377(1):75-80 PMID: 31598
  26. Rapid duplication and loss of genes coding for the alpha chains of hemoglobin.
    Proc Natl Acad Sci U S A. 1980 Apr;77(4):2158-62 PMID: 6929543
  27. The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.
    Cell. 1980 May;20(1):119-30 PMID: 6446404
  28. Complete amino acid sequences of the major early embryonic alpha-like globins of the chicken.
    J Biol Chem. 1980 Oct 10;255(19):9051-9 PMID: 6157691
  29. Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3586-9 PMID: 6158051
  30. Human embryonic haemoglobins Gower 1 and Gower 2.
    Nature. 1979 Jul 12;280(5718):162-4 PMID: 95353
  31. The primary structure of the human epsilon-globin gene.
    Cell. 1980 Oct;21(3):621-6 PMID: 6254663
  32. The nucleotide sequence of the human beta-globin gene.
    Cell. 1980 Oct;21(3):647-51 PMID: 6254664
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.10.6076
Published
1981-10-00
Pages
6076-80
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348980
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.10.6076 PMC Full Text View journal details
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