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PMID: 6091047 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.

Nucleic acids research ·Vol. 12 ·No. 18 ·1984-09-25 ·Pages 6965-77

Higgs DR, Hill AV, Bowden DK, Weatherall DJ, Clegg JB

Abstract

We have examined the molecular structure of the human alpha globin gene complex from individuals with a common form of alpha thalassaemia in which one of the duplicated pair of alpha genes (alpha alpha) has been deleted (-alpha 3-7). Restriction mapping and DNA sequence analysis of the mutants indicate that different -alpha 3.7 chromosomes are the result of at least three independent events. In each case the genetic crossover has occurred within a region of complete homology between the alpha 1 and alpha 2 genes. Since the -alpha chromosomes may reflect the processes of crossover fixation and gene conversion between the two genes, their structures may provide some insight into the mechanism by which the concerted evolution of the human alpha globin genes occurs.

MeSH Terms
Base Sequence Biological Evolution Cloning, Molecular DNA Restriction Enzymes DNA, Recombinant/metabolism Genes Globins/genetics Humans Polymorphism, Genetic Thalassemia/genetics
Chemicals
DNA, Recombinant Globins DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Higgs D R
Hill A V
Bowden D K
Weatherall D J
Clegg J B
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19 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.18.6965
Published
1984-09-25
Pages
6965-77
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320136
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/12.18.6965 PMC Full Text View journal details
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