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PMID: 3083400 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

A processed chicken pseudogene (CPS1) related to the ras oncogene superfamily.

Nucleic acids research ·Vol. 14 ·No. 5 ·1986-03-11 ·Pages 2123-38

Alsip GR, Konkel DA

Abstract

We describe the first polyA-containing processed pseudogene reported in the chicken. It includes a 0.52 kb open reading frame which could encode a 175 amino acid protein. The putative protein shows extensive homology to the ras oncogene superfamily, being most closely related to the yeast protein YP2. It is one of the two most divergent members of the ras superfamily yet described and is the most homologous of any ras-related protein to the G-protein alpha-transducin. The chicken genome contains at least one other gene highly homologous to CPS1; at least one member of the CPS1 family is active, but only early in chicken development. This pattern of expression, and the presence of mutations in regions known to activate human c-ras genes to oncogenicity, suggest that CPS1 may represent a new oncogene family.

MeSH Terms
Animals Base Sequence Chickens/genetics Cloning, Molecular DNA, Fungal/genetics GTP-Binding Proteins/genetics Gene Conversion Oncogenes Saccharomyces cerevisiae/genetics Sequence Homology, Nucleic Acid
Chemicals
DNA, Fungal GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Alsip G R
Konkel D A
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40 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.5.2123
Published
1986-03-11
Pages
2123-38
Language
English
Region
England
NLM ID
0411011
PMCID
PMC339647
Subset
IM
Grants
NINDS NIH HHS · NS17026 · United States
Databases
GENBANK
X03682
External Links
PubMed source DOI: 10.1093/nar/14.5.2123 PMC Full Text View journal details
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